关键词: 非布司他, 痛风, 慢性肾功能不全, 老年患者

Abstract: Objective To evaluate the clinical effect and the influence on renal function of the elderly gout patients with chronic renal insufficiency treated by febuxostat. Methods A retrospective analysis of 89 elderly gout patients with chronic renal insufficiency from January 2014 to December 2018 was made. The changes of serum uric acid （UA），urea nitrogen（BUN），serum creatinine（Scr），and estimated glomerular filtration rate（eGFR） before and after treatment with febuxostat were compared. Results ① After treatment，the UA and Scr of elderly gout patients with chronic renal insufficiency were significantly reduced，with statistical significance，and eGFR was significantly increased，with statistical significance. There was no significant change in BUN before and after treatment. ② Compared with before treatment， UA in each group was significantly reduced after febuxostat treatment，the difference was statistically significant，eGFR was significantly increased in patients with CKD stage 2-3，the difference was statistically significant，and there was no significant change in patients with CKD stage 4，and the difference was not statistically significant. Conclusion In the treatment of elderly gout patients with chronic renal insufficiency，febuxostat is effective in lowering uric acid levels，and it has a better effect on improving renal function in patients with CKD stage 2-3. However，for elderly gout patients who have reached CKD stage 4，the effects of febuxostat are not obvious on renal function，which may be related to the small sample size in the study. More clinical data and longer clinical observation are needed for the cardiovascular safety/risk of febuxostat in China.

Key words: febuxostat, gout, chronic renal insufficiency, elderly patients