腹外侧视前区微量注射组胺对大鼠睡眠-觉醒周期的影响

江汉大学学报（自然科学版） ›› 2015, Vol. 43 ›› Issue (1): 84-87.

腹外侧视前区微量注射组胺对大鼠睡眠-觉醒周期的影响

刘宇炜，文若剑，陈晓青，易卉玲，黄丹

江汉大学医学院，湖北武汉 430056

出版日期:2015-02-28 发布日期:2015-03-05
作者简介:刘宇炜（1973—），男，副教授，博士，研究方向：神经生物学。
基金资助:
国家自然科学基金面上项目（31371090）；武汉市科技计划项目（201250499145-27）

Effects of Microinjection of Histamine in Ventrolateral Preoptic Area on Rat Sleep-Wakefulness Cycle

LIU Yuwei，WEN Ruojian， CHEN Xiaoqing，YI Huiling，HUANG Dan

School of Medicine，Jianghan University，Wuhan 430056，Hubei，China

Online:2015-02-28 Published:2015-03-05

摘要/Abstract

摘要： 目的研究组胺作用于腹外侧视前区对大鼠睡眠-觉醒周期的影响。方法通过脑立体定位、腹外侧视前区微量注射组胺，脑电图仪记录及分析睡眠、觉醒时相。结果微量注射 50 μmol/L 组胺无明显影响，而 100μmol/L组胺显著减少大鼠睡眠，增加觉醒。结论组胺在腹外侧视前区对大鼠睡眠-觉醒周期发挥重要的调节作用，具有明显的促觉醒作用。

关键词: 组胺, 腹外侧视前区, 睡眠-觉醒周期

Abstract: Objective To study the effect of histamine in rat ventrolateral preoptic area on sleep-wakeful?ness cycle. Methods Histamine was microinjected into ventrolateral preoptic area through stereotaxic technique，sleeping and waking time phases were recorded and analyzed by electroencephalograph.Results Microinjection of 50 μmol/L histamine had no significant effect，but 100 μmol/L histamine decreased sleeping time and increased waking time significantly. Conclusion Histamine is involved in regulation of sleep-waking cycle and promotes wakefulness significantly in the ventrolateral preoptic area.

Key words: histamine, ventrolateral preoptic area, sleep-wakefulness cycle

中图分类号:

R338.8

刘宇炜，文若剑，陈晓青，易卉玲，黄丹. 腹外侧视前区微量注射组胺对大鼠睡眠-觉醒周期的影响[J]. 江汉大学学报（自然科学版）, 2015, 43(1): 84-87.

LIU Yuwei，WEN Ruojian， CHEN Xiaoqing，YI Huiling，HUANG Dan. Effects of Microinjection of Histamine in Ventrolateral Preoptic Area on Rat Sleep-Wakefulness Cycle[J]. Journal of Jianghan University(Natural Science Edition), 2015, 43(1): 84-87.