更昔洛韦口腔崩解片的研制及临床效用评价

江汉大学学报（自然科学版） ›› 2014, Vol. 42 ›› Issue (6): 71-74.

更昔洛韦口腔崩解片的研制及临床效用评价

赵梦遐¹，柯桂蓉²，贺盛亮^3*

1 . 湖北科技学院护理学院，湖北咸宁 437000；2 . 枝江石化医院，湖北宜昌 443200；3 . 咸宁市咸安区食品药品监督管理局马桥食品药品监管所，湖北咸宁 437020

出版日期:2014-12-25 发布日期:2014-12-26
通讯作者: 贺盛亮
作者简介:赵梦遐（1987—），女，助教，硕士，研究方向：护理教学与管理。
基金资助:
咸宁市咸安区科技立项（2014（14））

Development and Evaluation of Clinical Effect of Ganciclovir OralDisintegrating Tablet

ZHAO Mengxia¹, KE Guirong²，HE Shengliang^3*

1. Nursing College, Hubei University of Science and Technology，Xianning 437000， Hubei， China；2. Zhijiang Sinopec Hospital ， Yichang 443200， Hubei， China；3. Maqiao Food and Drug Supervision Station of Supervision and Management Bureau in Xian′ an District ， Xianning 437020， Hubei， China

Online:2014-12-25 Published:2014-12-26

摘要/Abstract

摘要： 目的 研制更昔洛韦口腔崩解片并运用于临床进行效用评价。方法以更昔洛韦为原料药制备成口腔崩解片，采用紫外分光光度法和反相高效液相色谱法控制其质量。并配合运用于艾滋病合并巨细胞病毒视网膜炎患者的治疗。结果性状、鉴别、检查、含量测定等考察指标符合质量控制的要求，运用治疗艾滋病合并巨细胞病毒视网膜炎的治愈有效率为85. 71% 。结论研制的更昔洛韦口腔崩解片质量稳定，质量分析方法可行性强。临床辅助用于艾滋病合并巨细胞病毒视网膜炎的治疗效果显著。

关键词: 更昔洛韦, 口腔崩解片, 临床运用

Abstract: Objective To develop the ganciclovir oral disintegrating tablet and evaluate the clinical utility. Methods Using ganciclovir as raw material medicine to develop orally disintegrating tablet，controlling the quality with ultraviolet spectrophotometric method and HPLC method，applying for the treatment of AIDS patients complicated with cytomegalovirus retinitis. Results The characters，identification，inspection，content determination indexes meet the quality control requirement，the effective rate for the curative treatment of AIDS patients with cytomegalovirus retinitis was 85. 71%.Conclusion The anciclovir oral disintegrating tablet developed had stable quality，and the quality analysis method is feasible. The adjuvant treatment of AIDS complicated with cytomegalovirus retinitis has obvious effect.

Key words: ganciclovir , oral disintegrating tablet, clinical application

中图分类号:

R 978 . 7

赵梦遐，柯桂蓉，贺盛亮. 更昔洛韦口腔崩解片的研制及临床效用评价[J]. 江汉大学学报（自然科学版）, 2014, 42(6): 71-74.

ZHAO Mengxia, KE Guirong，HE Shengliang. Development and Evaluation of Clinical Effect of Ganciclovir OralDisintegrating Tablet[J]. Journal of Jianghan University(Natural Science Edition), 2014, 42(6): 71-74.