江汉大学学报(自然科学版) ›› 2014, Vol. 42 ›› Issue (5): 50-52.

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老年冠心病患者血清胱抑素C水平与冠状动脉狭窄程度的相关性研究

姚 峰, 张苏川*   

  1. 江汉大学 附属医院心内科, 湖北 武汉 430015
  • 出版日期:2014-10-25 发布日期:2014-11-11
  • 通讯作者: 张苏川
  • 作者简介:姚 峰 (1979—) , 女, 主治医师, 硕士, 研究方向: 心血管病临床。

Correlation of Cystatin C Level and Coronary Artery Stenosis Degree in Aged Coronary Heart Disease

YAO Feng , ZHANG Suchuan*   

  1. Department of Cardiovasology, Affiliated Hospital of Jianghan University, Wuhan 430015, Hubei, China
  • Online:2014-10-25 Published:2014-11-11
  • Contact: ZHANG Suchuan
  • About author:张苏川 (1963—) , 男, 主任医师, 硕士, 研究方向: 心血管病临床。E-mail: zhangsuchuang@163.com

摘要: 目 的 研究血清胱抑素C (Cys C) 水平对老年冠心病患者冠状动脉狭窄程度的临床预测价值。方 法 回顾性分析185例经冠脉造影诊断为冠心病的老年患者, 根据冠状动脉造影检查结果分为单支病变组(89例) 及多支病变组 (96例) , 对所有入选患者进行Cys C检测并进行Gensini评分, 分析比较两组患者Cys C水平的差异及 Cys C 与冠状动脉照影 Gensini评分的相关性。结 果 (1) 多支病变组血清胱抑素 C 水平(1. 55±0. 32)mg/L明显高于单支病变组 (1. 28±0. 20) mg/L(P<0. 01) 。(2) 两组患者血清胱抑素C水平均与冠脉造影Gensini评分呈正相关 (多支病变组r=0. 78, P<0. 01; 单支病变组r=0. 75, P<0. 01) 。结 论 CysC水平检测能预测老年患者冠状动脉病变严重程度, 且随着Cys C水平的增高, 冠状动脉狭窄程度加重。

关键词: 血清胱抑素C, 冠状动脉狭窄, Gensini评分, 老年患者

Abstract: Objective To study the clinical predictive value of Cystatin C(Cys C)level to coronary artery stenosis degree of aged Coronary Heart Disease(CHD) . Methods Retrospectively analyzed 185 cases of aged CHD diagnosed with coronary angiography. According to the results of coronary angiography,185 cases were divided into single lesion group(89 cases)and multivessel lesions group(96 cases) ,detected Cys C level and graded Gensini score in all selected cases,analyzed the difference of level of Cys C,also the correlation of Cys C level and the coronary artery Gensini score in two groups. Results (1) The Cys C levels in multivessel lesions group( (1. 55±0. 32) mg/L)was obviously higher than that in single lesion group( (1. 28 ± 0. 20)mg/L) (P<0. 01) . (2)In two groups,the Cys C levels were positive correlated with Gensini score(multivessel leisions group,r=0. 78,P<0. 01;single lesion group,r=0. 75,P<0. 01) . Conclusion With Cys C level detecting,the coronary artery lesion degree can be predicted,as the increasing of Cys C level,the artery stenosis degree become more seriously.

Key words: Cystatin C, coronary artery stenosis, Gensini score, aged patient

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