关键词: 慢性阻塞性肺疾病, 代谢综合征, 辛伐他汀

Abstract: Objective：To investigate the functional mechanism and impact of simvastatin intervention in patients with chronic obstructive pulmonary disease complicated with metabolic syndrome. Methods：60 patients with chronic obstructive pulmonary disease with metabolic syndrome in stationary phase were randomly divided into intervention group and control group. The intervention group was given additional oral simvastatin 8 weeks for a cycle. CAT scores，pulmonary function and the levels of plasma C-reactive protein （CRP），interleukin-6 （IL-6），interleukin-8 （IL-8），SOD，blood lipids were recorded before and after treatment. Results： The CAT scores and CRP levels， interleukin-6（IL-6），interleukin-8（IL-8），SOD，blood lipids decreased in interventiong group after treatment；compared the intervention group before and after treatment，and compared intervention group after treatment to control group after treatment，there was statisticat difference（P<0.05）；in control group， compared before treatment to after treatment，there was no statistical difference. In comparison of FEV1，FEVl％，in intervention group and in control group before and after treatment，between the two groups also，there were no statistical differences（P > 0. 05） . Conclusion：Short term simvastatin treatment can improve the clinical symptoms and reduce the CRP and inflammatory mediators levels in patients with COPD，improve the quality of life，reduce the level of lipids. but can not improve lung function.