原发性高血压患者血尿酸、血胱抑素C和肌酐值的观察

江汉大学学报（自然科学版） ›› 2012, Vol. 40 ›› Issue (1): 98-100.

原发性高血压患者血尿酸、血胱抑素C和肌酐值的观察

张洪波

江汉大学附属医院检验科，湖北武汉430015

出版日期:2012-02-20 发布日期:2013-11-07
作者简介:张洪波单位1966—)，男，副主任技师，研究方向:临床生物化学。检验

A Survey of Serum Uric Acid, Cystatin C and CreatinineLevels in Essential Hypertension

ZHANG Hong－bo

Department of Clinical Laboratory,Affiliated Hospital,Jianghan University,Wuhan 430015,Hubei,China

Online:2012-02-20 Published:2013-11-07

摘要/Abstract

摘要： 目的观察原发性高血压单位EH)患者血尿酸单位UA)、血胱抑素C单位CysC)和肌酐单位Cr)值，探讨其临床意义。方法血尿酸和肌酐用酶法在全自动生化分析仪上测定，血胱抑素用比浊法在特定蛋白仪上测定。结果200例EH患者伴发高尿酸血症单位HUA)88例，其CysC值单位1.12±0.14)mg／L和Cr值单位141.5±93.5)μmol／L明显高于非HUA者单位P＜0.05);随着年龄的增长和高血压分期的增加而明显升高，但Cr升高率明显后于CysC的升高率和HUA的发生率单位P＜0.05)。结论EH患者CysC、Cr与HUA关系密切;UA、CysC升高在Cr之前;UA是EH患者肾损害的早期表现。

关键词: 原发性高血压, 尿酸, 肌酐, 胱抑素C

Abstract: ObjectiveTo survey serum uric acid单位 UA), cystatin C单位 Cys C) and creatinine单位 Cr) levels in patients with essential hypertension单位 EH), and study its clinical significance. MethodsUA and Cr were measured by enzymatic method with automatic biochemistry analyzer,Cys C was measured by nephelometry with specific protein aparatus. Results88 cases were accompanied with hyperuricemia 单位 HUA) in 200 patients with EH. Their mean Cys C value单位 1.12±0.14) mg/L and mean Cr value单位 141.5±93.5) μmol/L were higher than those in the patients without HUA significantly单位 P＜0.05), and increased with the growth of age and stages of hypertension. However, the rising rate of Cr value was lower than Cys C and HUA incidence单位 P＜0.05). ConclusionCys C and Cr values have close relation with HUA in patients with EH. UA and Cys C values rise before Cr value. UA is an early manifestation of impairment of renal function in patients with EH.

Key words: essential hypertension, uric acid, creatinine, cystatin C

中图分类号:

R544.110.2

张洪波. 原发性高血压患者血尿酸、血胱抑素C和肌酐值的观察[J]. 江汉大学学报（自然科学版）, 2012, 40(1): 98-100.

ZHANG Hong－bo. A Survey of Serum Uric Acid, Cystatin C and CreatinineLevels in Essential Hypertension[J]. Journal of Jianghan University(Natural Science Edition), 2012, 40(1): 98-100.

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