橘皮素缓解 APP/PS1 小鼠小胶质细胞过度激活及认知功能障碍

doi:10.16389/j.cnki.cn42-1737/n.2024.03.005

江汉大学学报（自然科学版） ›› 2024, Vol. 52 ›› Issue (3): 44-50.doi: 10.16389/j.cnki.cn42-1737/n.2024.03.005

• 医学 • 上一篇

橘皮素缓解 APP/PS1 小鼠小胶质细胞过度激活及认知功能障碍

于晶，梁征，贺子珊，陈鸿霖，石成英，龚晓康，包建，舒细记^*

江汉大学武汉生物医学研究院，湖北武汉 430056

发布日期:2024-06-17
通讯作者: 舒细记
作者简介:于晶（1995— ），女，硕士生，研究方向：神经退行性疾病。
基金资助:
湖北省自然科学基金面上项目（2022CFB456）

Tangeretin Alleviates Microglia Over-activation and Cognitive Impairment in APP/PS1 Mice

YU Jing，LIANG Zheng，HE Zishan，CHEN Honglin，SHI Chengying， GONG Xiaokang，BAO Jian，SHU Xiji^*

Wuhan Institute of Biomedical Sciences，Jianghan University，Wuhan 430056，Hubei，China

Published:2024-06-17
Contact: SHU Xiji

摘要/Abstract

摘要： 目的 观察橘皮素（tangeretin，TAN）对 APP/PS1 小鼠认知功能，以及脑内小胶质细胞过度激活和炎症因子分泌的影响。方法 2. 5 月龄雄性 APP/PS1 小鼠，通过口服给予 TAN，连续干预 16 周，观察 TAN 对缓解 APP/PS1 认知功能障碍，以及脑内小胶质细胞过度激活和炎症因子分泌的作用。结果 通过行为学检测发现 TAN 明显改善 APP/PS1 小鼠认知障碍；通过免疫荧光染色，发现 TAN 显著缓解 APP/PS1 小鼠脑内小胶质细胞的过度激活；多因子分析检测发现，TAN 显著升高小鼠脑内抑炎因子 IL-2 和 IL-5 的水平。结论 TAN 显著减轻 APP/PS1 小鼠脑内小胶质细胞过度激活以及调节炎症因子分泌，缓解小鼠的认知障碍。

关键词: 阿尔兹海默症, 橘皮素, 小胶质细胞, 炎症因子

Abstract: Objective To study the effects of tangeretin（TAN）on cognitive performance， microglia over-activation，and inflammatory factors released in APP/PS1 mice. Methods 2. 5-month-old male APP/PS1 mice were treated with TAN orally for 16 weeks. The effects of TAN on alleviating cognitive dysfunction of APP/PS1， microglia overactivation，and inflammatory factors released in the brain were observed. Results It was found that TAN significantly alleviated cognitive impairment in APP/PS1 mice by behavioral testing； the results of immunofluorescence staining demonstrated that TAN significantly alleviated microglia over-activation in the brain of APP/PS1 mice；the results of multifactor analysis showed that TAN significantly increased the levels of anti-inflammatory molecules IL-2 and IL-5 in the mouse brain. Conclusion TAN significantly reduces microglia over-activation，regulates the release of inflammatory factors in the brain of APP/PS1 mice，and alleviates cognitive impairment.

Key words: Alzheimer's disease, tangeretin, microglia, inflammatory factors

中图分类号:

于晶，梁征，贺子珊，陈鸿霖，石成英，龚晓康，包建，舒细记. 橘皮素缓解 APP/PS1 小鼠小胶质细胞过度激活及认知功能障碍[J]. 江汉大学学报（自然科学版）, 2024, 52(3): 44-50.

YU Jing，LIANG Zheng，HE Zishan，CHEN Honglin，SHI Chengying， GONG Xiaokang，BAO Jian，SHU Xiji. Tangeretin Alleviates Microglia Over-activation and Cognitive Impairment in APP/PS1 Mice[J]. Journal of Jianghan University (Natural Science Edition), 2024, 52(3): 44-50.

橘皮素缓解 APP/PS1 小鼠小胶质细胞过度激活及认知功能障碍

Tangeretin Alleviates Microglia Over-activation and Cognitive Impairment in APP/PS1 Mice

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