江汉大学学报(自然科学版) ›› 2022, Vol. 50 ›› Issue (6): 59-68.doi: 10.16389/j.cnki.cn42-1737/n.2022.06.007

• 医学 • 上一篇    下一篇

基于数据挖掘技术分析中药熏蒸治疗椎动脉型颈椎病的用药规律

张磊,潘天羽,任娇娇,任婷婷,游俊,朱书秀*   

  1. 江汉大学 医学院,湖北 武汉 430056
  • 发布日期:2022-12-19
  • 通讯作者: 朱书秀
  • 作者简介:张磊(1991— ),男,讲师,硕士,研究方向:中医药数据挖掘分析与应用。
  • 基金资助:
    江汉大学省内特色学科提升项目(03100041)

Analysis of Dosing Pattern of Chinese Medicine Fumigation for Vertebral Artery Type Cervical Spondylosis Based on Data Mining Technology

ZHANG Lei,PAN Tianyu,REN Jiaojiao,REN Tingting,YOU Jun,ZHU Shuxiu*   

  1. School of Medicine,Jianghan University,Wuhan 430056,Hubei,China
  • Published:2022-12-19
  • Contact: ZHU Shuxiu

摘要: 目 的 挖掘中药熏蒸治疗椎动脉型颈椎病的组方用药规律。方 法 以“颈椎病”或“项痹”和“中药熏蒸”为关键词,检索 CNKI、WanFang、VIP 建库至 2022 年 2 月 28 日的相关临床文献,使用 Excel 2016、SPSS Modeler 18.0、SPSS Statistics 26.0 统计软件为工具,对符合筛选标准的中药熏蒸处方进行频次分析、关联规则分析、因子分析及聚类分析。结 果 符合筛选标准的期刊文献53 篇,共涉及中药处方 64 首,共计 106 味中药,包含毒性中药 10 味。使用频次排名前 5 位的中药依次为红花、川芎、威灵仙、当归和羌活;中药分类主要以活血化瘀药、祛风湿药为主,四气以温性为主,五味以辛味为主,归经以肝经为主。毒性中药使用频次较高的为制川乌、艾叶、制草乌等,中药分类以祛风湿药、活血化瘀药为主,四气以热性为主,五味以苦、辛味为主,归经以肝经、脾经为主。关联规则分析得到核心中药组合 14 组,因子分析可提取公因子 6 个,系统聚类可聚为 4 类。结 论 中药熏蒸治疗椎动脉型颈椎病以祛风湿、活血化瘀为主,经数据挖掘技术对中药熏蒸方治疗椎动脉型颈椎病的组方规律进行分析,可为椎动脉型颈椎病的遣方用药和新药研发提供参考。

关键词: 中药熏蒸, 椎动脉型颈椎病, 数据挖掘, 用药规律

Abstract: Objective Excavating the grouping and medication rules of Chinese medicine fumigation for treating vertebral artery type cervical spondylosis. Methods Using ″ cervical spondylosis″ ,″ Xiang paralysis″ ,and ″ Chinese medicine fumigation″ as keywords,we searched the relevant literature from CNKI,WanFang,and VIP databases until February 28,2022. The frequency analysis,association rule analysis,factor analysis,and cluster analysis were performed on the Chinese medicine fumigation prescriptions with the inclusion criteria using Excel 2016,SPSS Modeler 18.0,and SPSS Statistics 26.0 statistical. Results 53 journal articles met the inclusion criteria,involving 64 prescriptions,106 herbs,and 10 toxic Chinese medicines. The top 5 high-frequency herbal medicines were Honghua,Chuanxiong,Weilingxian,Danggui,and Qianghuo. The classification of Chinese herbal medicines was mainly based on activating blood circulation and eliminating wind dampness,the four qi were mainly warm,the five tastes were mainly pungent,and the generalized meridian was mainly liver meridian. Toxic herbal medicines were more frequently used for Zhichuanwu,Aiye,Zhicaowu,etc. The classification of herbal medicines was mainly based on dispelling wind-dampness and invigorating blood stasis,the four qi were mainly hot,the five tastes were mainly bitter and pungent,and the generalized meridians were mainly liver meridians and spleen meridians. The formulae were analyzed by association rules to obtain 14 high-frequency drug combinations,and factor analysis could extract 6 common factors,which were grouped into 4 major categories by systematic clustering analysis. Conclusion Treating vertebral artery type cervical spondylosis by Chinese medicine fumigation is based on dispelling wind-dampness,activating blood circulation,and resolving blood stasis. Analyzing the formulae pattern of Chinese medicine fumigation for vertebral artery type cervical spondylosis by data mining technology can provide some reference for prescribing vertebral artery type cervical spondylosis and developing new drugs.

Key words: Chinese medicine fumigation, vertebral artery type cervical spondylosis, data mining, dosing pattern

中图分类号: