江汉大学学报(自然科学版) ›› 2021, Vol. 49 ›› Issue (2): 12-19.doi: 10.16389/j.cnki.cn42-1737/n.2021.02.002

• COVID-19 研究 • 上一篇    下一篇

新型冠状病毒引起消化系统表现的研究进展

岳静茹1a,2,李忠霞1a,2,张姮2,乔嘉璐*1a,1b   

  1. 1. 江汉大学 a. 医学院,b. 武汉生物医学研究院,湖北 武汉 430056;2. 武汉市中心医院 消化内科,湖北 武汉 430014
  • 发布日期:2021-03-19
  • 作者简介:岳静茹(1994— ),女,硕士生,研究方向:消化内科。
  • 基金资助:
    QIAO Jialu

Advances in Digestive System Performance Induced by SARS-CoV- 2

YUE Jingru1a,2,LI Zhongxia1a,2,ZHANG Heng2,QIAO Jialu*1a,1b   

  1. 1. a. School of Medicine,b. Wuhan Institute of Biomedical Sciences,Jianghan University,Wuhan 430056,Hubei,China;2. Department of Gastroenterology,The Central Hospital of Wuhan,Wuhan 430014,Hubei,China
  • Published:2021-03-19
  • Contact: 乔嘉璐

摘要: 新型冠状病毒肺炎(COVID-19)作为2019 年新发急性呼吸道传染病,在全球范围呈现大流行趋势,继而引发了大面积的人员伤亡和严重的经济损失,对全球各国公共卫生构成了严重威胁。COVID-19 已被确认是由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染引起。该病毒除侵犯呼吸系统外,还侵犯消化系统,主要引起腹泻、呕吐等消化道症状及肝功能异常等表现,且部分患者以消化道症状为首发表现,同时也有部分研究表明在患者粪便中也能检测到病毒RNA 存在,甚至可在粪便中直接找到病毒。结合现有诊治指南及国内外文献资料,就COVID-19 伴发消化系统表现的临床症状、发病机制、治疗及粪口传播进行综述,以期为临床医护人员预防和治疗COVID-19 提供参考。

关键词: COVID-19, SARS-CoV-2, 胃肠道感染, 肝损伤, 粪口传播

Abstract: As a new acute respiratory infectious disease in 2019,coronavirus disease 2019(COVID-19) shows a global epidemic trend,which leads to large casualties and serious economic losses,and poses a serious threat to public health worldwide. COVID-19 has been confirmed to be caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). Although COVID-19 is principally defined by its respiratory symptoms,it is clear that the virus can also affect the digestive system,which mainly causes gastrointestinal symptoms such as diarrhea, vomiting and abnormal liver function. Moreover,some patients have gastrointestinal symptoms as the first manifestation,and some studies have shown that the RNA of SARS-CoV-2 could be detected in the stool of infected patients. In this paper,we reviewed the clinical symptoms,pathogenesis,treatment,and faecal-oral transmission of COVID-19 associated with the digestive system based on the existing diagnosis and treatment guidelines and literature,in order to provide a reference for clinical medical staff to prevent and treat COVID-19.

Key words: COVID-19, SARS-CoV-2, gastrointestinal infection, liver injury, faecal-oral transmission

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