低位直肠癌非手术治疗后存活8 年1 例报道及文献复习

doi:10.16389/j.cnki.cn42-1737/n.2018.05.012

江汉大学学报（自然科学版） ›› 2018, Vol. 46 ›› Issue (5): 466-470.doi: 10.16389/j.cnki.cn42-1737/n.2018.05.012

低位直肠癌非手术治疗后存活8 年1 例报道及文献复习

房子健^1，2，李敏²，卜佳珺²，高畅²，刘灿²，谢亚蓉^1，2，冯觉平^*2

1.江汉大学医学院，湖北武汉 430056；2. 华中科技大学同济医学院附属普爱医院（江汉大学研究生培养基地）肿瘤科，湖北武汉 430034

出版日期:2018-10-28 发布日期:2018-10-25
通讯作者: 冯觉平
作者简介:房子健（1992—），男，硕士生，研究方向：结直肠癌治疗。
基金资助:
国家卫生计生委重大公共卫生服务项目（财社［2012］64号）

Eight Years Survival of Rectal Cancer with Non-surgical Treatment: a Case Report and Literature Review

FANG Zijian^1，2，LI Min²，BU Jiajun²，GAO Chang²，LIU Can²，XIE Yarong^1，2，FENG Jueping^*2

1. School of Medicine，Jianghan University，Wuhan 430056，Hubei，China；2. Department of Oncology，Puai Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430034，Hubei，China

Online:2018-10-28 Published:2018-10-25
Contact: FENG Jueping

摘要/Abstract

摘要： 目的 探讨直肠癌新辅助放化疗后临床完全缓解（cCR）而采用非手术治疗的“等待与观察”策略对直肠癌患者生存及生活质量的影响。方法 对1例低位直肠癌新辅助放化疗后cCR而未进行根治性手术的病例采用定期MRI、全结肠镜、CT、血清CEA、CA-199 等动态监测，随访8 年，并对相关文献进行复习。结果 患者新辅助放化疗后cCR，第3年出现多发肺转移，并接受化疗为主的综合治疗5年，至今存活8年，但生活质量明显降低。结论 直肠癌新辅助放化疗后cCR而采用非手术治疗的策略应当慎重。远处转移是影响患者生活质量及预后的重要原因之一。

关键词: 直肠癌, 新辅助放化疗, 非手术治疗

Abstract: Objective To investigate the effect of ″wait and observe″ strategy of non-surgical treatment on survival and quality of life in patients with rectal cancer and with clinical complete response（cCR）after neoadjuvant chemoradiotherapy. Methods One case of low rectal cancer with cCR after neoadjuvant chemoradiotherapy without radical surgery has been dynamically monitored for eight years by MRI，colonoscopy，CT，serum CEA，CA-199 and so on. Results The patient received neoadjuvant chemoradiotherapy to achieve cCR had multiple lung metastases in the third year，and received chemotherapy-based comprehensive treatment for five years，has survived for eight years. However，the quality of life was significantly reduced. Conclusion The strategy of non-surgical treatment for cCR after neoadjuvant chemoradiotherapy for rectal cancer should be carefully considered. Distant metastasis is one of the important factors affecting the quality of life and prognosis of patients.

Key words: rectal cancer, neoadjuvant chemoradiotherapy, non-surgical treatment

中图分类号:

R735.37

房子健，李敏，卜佳珺，高畅，刘灿，谢亚蓉，冯觉平. 低位直肠癌非手术治疗后存活8 年1 例报道及文献复习[J]. 江汉大学学报（自然科学版）, 2018, 46(5): 466-470.

FANG Zijian，LI Min，BU Jiajun，GAO Chang，LIU Can，XIE Yarong，FENG Jueping. Eight Years Survival of Rectal Cancer with Non-surgical Treatment: a Case Report and Literature Review[J]. Journal of Jianghan University(Natural Science Edition), 2018, 46(5): 466-470.

低位直肠癌非手术治疗后存活8 年1 例报道及文献复习

Eight Years Survival of Rectal Cancer with Non-surgical Treatment: a Case Report and Literature Review

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