尼莫同联合脑蛋白水解物治疗非痴呆型血管性认知障碍的临床观察

江汉大学学报（自然科学版） ›› 2012, Vol. 40 ›› Issue (2): 85-88.

尼莫同联合脑蛋白水解物治疗非痴呆型血管性认知障碍的临床观察

欧阳方，欧阳存

江汉大学附属医院神经内科，湖北武汉430015

出版日期:2012-04-20 发布日期:2013-11-07
作者简介:欧阳方(1984—)，男，主治医师，研究方向:神经内科临床。

Clinical Observation of Nimotop Combined with Cerebroprotein Hydrolysate Injection in the Treatment of VCIND

OUYANG Fang,OUYANG Cun

Department of Neurology,Affiliated Hospital,Jianghan University,Wuhan 430015,Hubei,China

Online:2012-04-20 Published:2013-11-07

摘要/Abstract

摘要： 目的评价尼莫同和脑蛋白水解物注射液治疗非痴呆型血管性认知障碍(VCIND)的疗效。方法将42例VCIND患者分为3组，各14例，A组口服尼莫同30mg，tid;B组脑蛋白水解物注射液90mg加入5％葡萄糖注射液(或0.9％氯化钠注射液)250mL缓慢静滴qd;C组尼莫同30mg，tid，联合脑蛋白水解物注射液90mg加入5％葡萄糖注射液(或0.9％氯化钠注射液)250mL缓慢静滴qd，疗程均为14d。2周治疗前后MoCA量表中文版及MMSE量表评分的变化，将结果进行统计学处理。结果2周内，尼莫同联合脑蛋白治疗组治疗后MoCA量表中文版评分较治疗前有明显改善，且较其他组明显，差异有统计学意义(P＜0.05)。单药治疗组治疗前后评分无显著改善，差异无统计学意义(P＞0.05)，而MMSE评分均无明显改善(P＞0.05)。结论按MoCA量表评定尼莫同联合脑蛋白治疗非痴呆型血管性认知障碍疗效显著，优于单独使用尼莫同及脑蛋白。

关键词: 非痴呆型血管性认知障碍, 尼莫同, 脑蛋白水解物, MoCA量表中文版, MMSE量表

Abstract: ObjectiveClinical observation of nimotop combined with cerebroprotein hydrolysate injection in the treatment of vascular cognitive impairment no dementia (VCIND) Methods42 VCIND cases were divided into three groups, each with 14 casesGroup A taking oral nimotop 30mg, tid; Group B injecting cerebroprotein hydrolysate injection 90mg in 5％ glucose injection (or 0.9％ sodium chloride injection) 250 mL slow intravenous infusion qd; Group C injecting nimotop 30mg, tid combined with cerebroprotein hydrolysate injection 90 mg in 5％ glucose injection (or 0.9％ sodium chloride injection) 250 mL slow infusion qd. Duration of treatment was 14 days. Two weeks before and after treatment, the Chinese version of MoCA scale and MMSE changes were taken. The results were analyzed statistically. ResultsWithin two weeks, the Chinese version of MoCA scale score of the combined treatment group was significantly improved compared with other groups. The difference was statistically significant(P < 0.05). Monotherapy before and after treatment score was no significant improvement. The MMSE scores were not improved (P ＞ 0.05). ConclusionRating scale by MoCAnimotop combined by cerebroprotein hydrolysate injection in treatment of VCIND were significantly superior to nimotop alone and to Cerebroprotein hydrolysate injection.

Key words: VCIND, nimotop, cerebroprotein hydrolysate injection, MoCA scale of Chinese version, MMSE

中图分类号:

欧阳方，欧阳存. 尼莫同联合脑蛋白水解物治疗非痴呆型血管性认知障碍的临床观察[J]. 江汉大学学报（自然科学版）, 2012, 40(2): 85-88.

OUYANG Fang,OUYANG Cun. Clinical Observation of Nimotop Combined with Cerebroprotein Hydrolysate Injection in the Treatment of VCIND[J]. Journal of Jianghan University(Natural Science Edition), 2012, 40(2): 85-88.