江汉大学学报(自然科学版) ›› 2018, Vol. 46 ›› Issue (5): 431-437.doi: 10.16389/j.cnki.cn42-1737/n.2018.05.007

• 材料科学 • 上一篇    下一篇

新型荧光纳米材料在核酸和蛋白质检测中的应用

陈朝会,张正涛,苏鲁方   

  1. 江汉大学 交叉学科研究院,湖北 武汉 430056
  • 出版日期:2018-10-28 发布日期:2018-10-25
  • 作者简介:陈朝会(1987—),女,助理研究员,博士,研究方向:纳米生物医学传感。
  • 基金资助:
    湖北省教育厅科学技术研究计划指导性项目(B2017264)

Application of Novel Fluorescent Nanomaterials on Detection of Nucleic Acids and Proteins

CHEN Chaohui,ZHANG Zhengtao,SU Lufang   

  1. Institute for Interdisciplinary Research,Jianghan University,Wuhan 430056,Hubei,China
  • Online:2018-10-28 Published:2018-10-25

摘要: 核酸是生物体内重要的遗传信息载体,在生命活动中起着存储和传递遗传信息的作用,决定着生物体的生长、遗传和变异等一系列重大的生命现象。蛋白质是生命活动的基础,许多重要的生命现象和生理活动都是通过蛋白质实现。蛋白质含量的变化与疾病息息相关,因此许多疾病相关蛋白的检测在病理学、基因组学等方面有重要的参考价值。近年来,随着纳米生物技术的发展,荧光纳米材料低毒、易于合成、成本低等优势使其成为建立新型分析方法的有力工具。介绍了常见的荧光纳米材料在核酸和蛋白荧光分析中的应用。

关键词: 新型荧光纳米材料, 核酸检测, 蛋白质检测, 生物传感

Abstract: Nucleic acid is very important in genetic information transmission and is closely related to a series of life phenomena such as growth,heredity and variation of living organisms. The variation of protein concentration can reflect the early stages of certain diseases. Therefore,the detection of proteins is valuable in disease diagnosis and genomics. Recently,with the development of nano-biotech? nology,fluorescent nanomaterials have emerged as a powerful tool for establishing new analytical methods due to their low toxicity,easiness of synthesis and low cost. In this review,we introduced the fundamental properties of the new fluorescent nanomaterials and focused on their recent applications on nucleic acid and protein analysis.

Key words: novel fluorescent nanomaterials, nucleic acid analysis, protein detection;biosensor

中图分类号: