黄连解毒汤治疗老年痴呆的Meta 分析

doi:10.16389/j.cnki.cn42-1737/n.2017.05.012

江汉大学学报（自然科学版） ›› 2017, Vol. 45 ›› Issue (5): 452-457.doi: 10.16389/j.cnki.cn42-1737/n.2017.05.012

黄连解毒汤治疗老年痴呆的Meta 分析

罗君¹，刘冰寒¹，陈国华^*2

1. 江汉大学医学院，湖北武汉 430056；2. 武汉市第一医院神经内科，湖北武汉 430022

出版日期:2017-10-28 发布日期:2017-10-31
通讯作者: 陈国华
作者简介:罗君（1986—），女，硕士生，研究方向：神经内科。

Meta Analysis of Huanglian Jiedu Decoction in Treatment of Senile Dementia

LUO Jun¹，LIU Binghan¹，CHEN Guohua^*2

1.School of Medicine，Jianghan University，Wuhan 430056，Hubei，China；2. Department of Neurology，Wuhan No.1 Hospital，Wuhan 430022，Hubei，China

Online:2017-10-28 Published:2017-10-31
Contact: CHEN Guohua

摘要/Abstract

摘要： 目的 系统评价黄连解毒汤治疗老年痴呆的有效性。方法 计算机检索相关文献，按照制定的标准筛选后，由2名研究者单独提取资料、交叉核对，将数据录入RevMan5.2 作统计分析。结果 共纳入6个研究，共539例患者，黄连解毒汤联合其他西药或中药为治疗组，单独的西药或中药治疗为对照组。Meta分析结果表明：① 比较治疗后的总有效率，黄连解毒汤联合其他西药或中药治疗效果明显高于对照组单独中药或西药治疗（OR = 3. 06，95％ CI（1. 11，8. 47）），差异具有统计学意义（ Z = 2. 16，P = 0. 03＜0. 05）。② 比较两组的认知功能（MMSE评分）（WMD = 1. 07，95％ CI（0. 53，1. 06）），差异具有统计学意义（ Z = 3. 90，P ＜0. 000 1）。③ 比较两组的日常生活能力ADL 评分，治疗组与对照组差异无统计学意义（WMD = -1. 01，95％ CI（-5. 64，3. 61），Z = 0. 43，P = 0. 67＞0. 05）。结论 黄连解毒汤联合其他西药或中药对老年痴呆患者日常生活能力影响差异无统计学意义，但对认知功能有的改善差异具有统计学意义，此研究表明黄连解毒汤联合其他西药或中药治疗老年痴呆效果显著优于单纯的中药或西药治疗，且无毒副反应，由于其制药方便且价格便宜，值得在临床进一步推广。

关键词: 老年痴呆, 黄连解毒汤, Meta 分析, 随机对照试验, 文献研究

Abstract: Objective To evaluate the effectiveness of Hunaglian Jiedu Decoction in treatment of senile dementia patients systematically. Methods In the first place，the writers retrieved relevant literature by computer. After screening them according to the established standards，two researchers extracted the information independently，and cross checked the information，then input the data to RevMan5.2 for statisticanalysis. Results Six researches consisted of 539 patients have been adopted. Treatment group：patients treated by Huanglian Jiedu Decoction in combination with other western medicine or traditional Chinese medicine. Control group：patients treated by western medicine or traditional Chinese medicine. The Meta analysis results showed：1）To compare the total effective rate after treatment，the therapeutic effect of treatment group was obviously higher than that of control group( OR =3. 06，95%CI （1. 11，8. 47）），the difference was statistically significant（ Z =2. 16，P =0. 03＜0. 05）；2）To compare the cognitive function of the two groups（MMSE Score）( WMD = 1. 07，95% CI （0. 53， 1. 06）），the difference was statistically significant（ Z = 3. 90， P < 0. 000 1 < 0. 05）；3）Tocompare the ability of daily life of the two groups（ADL Score），the difference was not statistically significant between the two groups ( WMD =1. 01，95% CI （-5. 64，3. 61）， Z = 0. 43， P = 0. 67>0. 05). Conclusion The group treated by Huanglian Jiedu Decoction in combination with other western medicine or traditional Chinese medicine and the group treated by western medicine or traditional Chinese medicine，the difference is not statistically significant in the impact of daily life ability between them. While in improvement of cognitive function，the difference is statistically significant. This research indicates that the effects of treatment group are much better than the effects of control group. On account of its pharmaceutical convenience，cheap price and non-toxic and non-side effects，the therapeutic method is worthy of popularization in clinic.

Key words: senile dementia patients, Huanglian Jiedu Decoction, Meta analysis, randomized controlled trial, literature research

中图分类号:

R742.890.5

罗君，刘冰寒，陈国华. 黄连解毒汤治疗老年痴呆的Meta 分析[J]. 江汉大学学报（自然科学版）, 2017, 45(5): 452-457.

LUO Jun，LIU Binghan，CHEN Guohua. Meta Analysis of Huanglian Jiedu Decoction in Treatment of Senile Dementia[J]. Journal of Jianghan University(Natural Science Edition), 2017, 45(5): 452-457.

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黄连解毒汤治疗老年痴呆的Meta 分析

Meta Analysis of Huanglian Jiedu Decoction in Treatment of Senile Dementia

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