江汉大学学报(自然科学版) ›› 2025, Vol. 53 ›› Issue (5): 78-84.doi: 10.16389/j.cnki.cn42-1737/n.2025.05.009

• 医学 • 上一篇    

产后体重滞留增加再次妊娠罹患妊娠期糖尿病的风险

李乾玉1,刘姗姗2,杨 蓉*2   

  1. 1. 江汉大学 医学部,湖北 武汉 430056; 2. 华中科技大学 同济医学院附属武汉儿童医院(武汉市妇幼保健院),湖北 武汉 430016
  • 发布日期:2025-10-22
  • 通讯作者: 杨 蓉
  • 作者简介:李乾玉(1999—),女,硕士生,研究方向:妇女保健。
  • 基金资助:
    湖北省自然科学基金项目(2018CFC855)

Risk Increase of Developing Gestational Diabetes Mellitus in the Second Pregnancy by Postpartum Weight Retention

LI Qianyu1,LIU Shanshan2,YANG Rong*2   

  1. 1. School of Medicine,Jianghan University,Wuhan 430056,Hubei,China;2. Wuhan Children′s Hospital (Wuhan Maternal and Child Healthcare Hospital),Tongji Medical College,Huazhong University of Science & Technology,Wuhan 430016,Hubei,China
  • Published:2025-10-22
  • Contact: YANG Rong

摘要: 目 的 评估产后体重滞留(postpartumweight retention,PPWR)与再次妊娠罹患妊娠期 糖尿病(gestational diabetes mellitus,GDM)发生风险之间的关系。方 法 以2019年1月1日到2022年12月31日期间再次分娩单活胎的武汉市常住孕产妇为研究对象,从妇幼信息系统中提取 产妇的基本信息、产前检查和分娩信息,采用logistic回归分析PPWR与再次妊娠时发生GDM之间的关系。结 果 本研究共纳入3518名产妇,2327人(66.1%)有产后体重滞留,其中31.1% (1 095人)有高体重滞留。487人(13.8%)再次妊娠时患有GDM。回归分析结果显示初次分娩后出现高体重滞留的产妇再次妊娠时罹患GDM的风险提高了38%(OR1.38,95%CI(1.09,1. 74)),调整了相关因素后,这一风险增加到41%(aOR 1.41,95%CI(1.11,1.79))。进一步分析显示在首次妊娠出现高体重滞留的人群中,即便首次妊娠未患GDM,再次妊娠患GDM的风险亦增加了53%(OR 1.53,95%CI(1.17,2.01);调整后OR 1.57,95%CI(1.19,2.06))。结 论 初次分娩后高体重滞留增加了再次妊娠GDM的发生风险,应高度关注产后体重管理。

关键词: 产后体重滞留, 再次妊娠, 妊娠期糖尿病

Abstract: Objective To evaluate the association between postpartum weight retention (PPWR)and the risk of developing gestational diabetes mellitus(GDM) in the second pregnancy. Methods Taking the permanent puerperal women in Wuhan who second delivered a singleton from January 1,2019,to December 31,2022,the maternal basic information, prenatal examination,and delivery information were extracted from the maternal and child information system,and the relationship between PPWR and GDM during the second pregnancy was analyzed by logistic regression. Results A total of 3 518 pregnant women were included in this study,2 327 pregnant women(66. 1%)had postpartum weight retention,of which 31. 1%(1 095 pregnant women)had high weight retention. 487 pregnant women (13. 8%)had GDM in the next pregnancy. Regression analysis showed that women with high weight retention after their first delivery had a 38% increased risk of developing GDM in their second pregnancy(OR 1. 38,95%CI(1. 09,1. 74)),after adjusting for relevant factors, this risk increased to 41%(aOR 1. 41,95%CI(1. 11,1. 79)). Further analysis showed that among those with high weight retention in a first pregnancy,the risk of developing GDM in a second pregnancy increased by 53%(OR 1. 53,95%CI(1. 17,2. 01);aOR 1. 57,95%CI (1. 19,2. 06)),even if the first pregnancy did not develop GDM. Conclusion High weight retention after the primary delivery increases the risk of developing GDM in the second pregnancy,and postpartum weight management should be given high attention.

Key words: postpartum weight retention, second pregnancy, gestational diabetes mellitus

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