关键词: 自闭症谱系障碍, 动物模型, 造模方案

Abstract: Autism spectrum disorder （ASD） is a group of neurodevelopmental diseases characterized by difficulties in social interactions as well as verbal communication，repetitive behaviors，and a narrow range of interests or activities. ASD seriously affects the growth， development，and daily life of patients. Therefore，establishing animal models of ASD induced by different factors has an important reference value for revealing its pathogenesis and developing new clinical interventions and treatment strategies. In this review，we summarized the experimental animal models of ASD and their modeling schemes to provide clues and a basis for further research on the pathogenesis of ASD.

Key words: autism spectrum disorder, animal models, modeling schemes