关键词: 脑膜瘤, 免疫组织化学, 鉴别诊断

Abstract: Objective To investigate clinicopathological features and differential diagnosis of intracranial meningioma. Methods 137 cases of intracranial meningioma were examined by routine HE and immunohistochemical staining and followed up. At the same time， clinicopathological characteristics were analyzed based on the review of relevant literature. ResultsThe morphology of these lesions was rich and varied，and most cases were WHO grade I. In some cases，a small number of atypic cells，flaky necrotic areas，and skull invasion could be seen，and there was a possibility of recurrence. The expression of tumor cellswaspositive inPCK，Vim，andEMA. Ki-67 increment indexwas2%-35%with the increaseof tumor grade. p53wasdiffuselypositive ina small number ofWHOgrade I andhigh-grade lesions. SOX2waspositivelyexpressed inhigh-grade tumor cells. ER α36 was strongly expressed in some cases. The 45 cases were followed up after the operation，and the results were relapse in 8 cases and death in 7 cases. Conclusion Meningiomasare themost commoncentral nervous systemtumors，andmostmeningiomas belong to benign tumors. However，some of these cases have the biological behavior of invasive potential and relapse tendency. The combined detection of immunohistochemical indexes p53，Ki-67，andSOX2 can help to screen out such cases and provide help for clinical treatment andprognosis. ThepositiveexpressionofER-α36protein insomecases ofmeningiomamayprovideanewresearchdirectionfor thepathogenesisof thisdisease.

Key words: meningioma, immunohistochemistry, differentialdiagnosis